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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma (PDAC)

ABSTRACT: Determine methylation pattern in PDAC a genome-wide analysis was performed in a cohort of 167 PDAC and 29 adjacent pancreatic tissues samples using the Infinium 450k methylation arrays (Illumina). 167 pancreatic tumors (PDAC) x 29 adjacent -non tumor samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Katia Nones

PROVIDER: E-GEOD-49149 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling.

Nones Katia K Waddell Nic N Song Sarah S Patch Ann-Marie AM Miller David D Johns Amber A Wu Jianmin J Kassahn Karin S KS Wood David D Bailey Peter P Fink Lynn L Manning Suzanne S Christ Angelika N AN Nourse Craig C Kazakoff Stephen S Taylor Darrin D Leonard Conrad C Chang David K DK Jones Marc D MD Thomas Michelle M Watson Clare C Pinese Mark M Cowley Mark M Rooman Ilse I Pajic Marina M Butturini Giovanni G Malpaga Anna A Corbo Vincenzo V Crippa Stefano S Falconi Massimo M Zamboni Giuseppe G Castelli Paola P Lawlor Rita T RT Gill Anthony J AJ Scarpa Aldo A Pearson John V JV Biankin Andrew V AV Grimmond Sean M SM

International journal of cancer 20140509 5

The importance of epigenetic modifications such as DNA methylation in tumorigenesis is increasingly being appreciated. To define the genome-wide pattern of DNA methylation in pancreatic ductal adenocarcinomas (PDAC), we captured the methylation profiles of 167 untreated resected PDACs and compared them to a panel of 29 adjacent nontransformed pancreata using high-density arrays. A total of 11,634 CpG sites associated with 3,522 genes were significantly differentially methylated (DM) in PDAC and ...[more]

PMID: 24500968

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Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma (PDAC)

Project description:Determine methylation pattern in PDAC a genome-wide analysis was performed in a cohort of 167 PDAC and 29 adjacent pancreatic tissues samples using the Infinium 450k methylation arrays (Illumina).

2014-07-08 | GSE49149 | GEO

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2015-01-01 | E-GEOD-59999 | biostudies-arrayexpress

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Methylation profiling by array of pancreatic adenocarcinoma (PDAC) xenografts

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