Comparison of the expression profiles of 630E strain and a hfQ mutant after 7.5h of growth in Tyt

ABSTRACT: Clostridium difficile is an emergent human pathogen and the most common cause of nosocomial diarrhea. Our recent deep-sequencing data strongly suggest the importance of RNA-based mechanisms for the control of gene expression in C. difficile. The RNA chaperon protein Hfq is a key component of post-transcriptional regulatory network in various bacterial systems. In an effort to understand the function of Hfq in C. difficile, we have constructed and characterized an Hfq-depleted strain in this bacterium. We present evidence that Hfq is necessary for the normal cell growth, for the establishment of bacillary form and might be involved in metabolic adaptations, stress response and sporulation, important during C. difficile infection cycle. In accordance to these phenotypic changes, our transcri

ORGANISM(S): Peptoclostridium difficile

SUBMITTER: Monot Marc 

PROVIDER: E-GEOD-49168 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress