Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide analysis of the miR profile in human head and neck paraganglioma vs. Jacobson's (tympanic) nerve and SH-SY5Y neuroblastoma cells

ABSTRACT: The aim of the study was to assess whether changes in the expression of miRs could be implicated in the modulation of the NOTCH pathway in head and neck paragangliomas. Several miRs, notably including families (miR-34s, miR-200s) that target the NOTCH signaling pathway, resulted differentially expressed in paragangliomas compared to the reference normal tissue, i.e., Jacobson's nerve. Total RNA from paraganglioma samples compared to total RNA from Jacobson's nerves (normal controls, chosen because Jacobson's nerve is a frequent site of origin of tympanic paraganglioma) and from SH-SY5Y cells (chosen based on their sympathoadrenal origin).

ORGANISM(S): Homo sapiens

SUBMITTER: Renato Mariani-Costantini 

PROVIDER: E-GEOD-49190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Head and neck paragangliomas, rare neoplasms of the paraganglia composed of nests of neurosecretory and glial cells embedded in vascular stroma, provide a remarkable example of organoid tumor architecture. To identify genes and pathways commonly deregulated in head and neck paraganglioma, we integrated high-density genome-wide copy number variation (CNV) analysis with microRNA and immunomorphological studies. Gene-centric CNV analysis of 24 cases identified a list of 104 genes most significantly  ...[more]

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