Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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SUDHL-4 cells: suspension vs. co-cultured with HK cells

ABSTRACT: We first performed miRNA analysis on SU-4 cells in suspension, and after 24 and 48 h of HK co-culture. To ensure that no HK cell contamination occurred, SU-4 cells in suspension and after co-culture were purified by CD19-positive magnetic selection, followed by total RNA isolation. Two-condition experiment, S4 vs. S4+HK cells. Biological replicates: 2 suspension controls, 2 co-cultured with HK cells, independently grown and harvested. One replicate per array.

ORGANISM(S): Homo sapiens

SUBMITTER: jianguo tao 

PROVIDER: E-GEOD-49253 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A microenvironment-mediated c-Myc/miR-548m/HDAC6 amplification loop in non-Hodgkin B cell lymphomas.

Lwin Tint T   Zhao Xiaohong X   Cheng Fengdong F   Zhang Xinwei X   Huang Andy A   Shah Bijal B   Zhang Yizhuo Y   Moscinski Lynn C LC   Choi Yong Sung YS   Kozikowski Alan P AP   Bradner James E JE   Dalton William S WS   Sotomayor Eduardo E   Tao Jianguo J  

The Journal of clinical investigation 20131101 11

A dynamic interaction occurs between the lymphoma cell and its microenvironment, with each profoundly influencing the behavior of the other. Here, using a clonogenic coculture growth system and a xenograft mouse model, we demonstrated that adhesion of mantle cell lymphoma (MCL) and other non-Hodgkin lymphoma cells to lymphoma stromal cells confers drug resistance, clonogenicity, and induction of histone deacetylase 6 (HDAC6). Furthermore, stroma triggered a c-Myc/miR-548m feed-forward loop, link  ...[more]

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