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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide analysis of AR-responsive gene expression in prostate cancer cells

ABSTRACT: Analysis of AR-regulation of gene expression. The hypothesis tested in the present study was that AR influences the expression of genes that participate in important bioprocesses in prostate cancer cells, including cell cycle, DNA replication, recombination and repair. Results provide important information on AR-responsive genes that may be crucial to the cell survival and the progression of prostate cancer. Total RNA obtained from AR siRNA-transfected prostate cancer cells compared to negative control siRNA-transfected prostate cancer cells 48 h after siRNa transfection.

ORGANISM(S): Homo sapiens

SUBMITTER: Timothy Thompson

PROVIDER: E-GEOD-49285 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide analysis of AR-responsive gene expression in prostate cancer cells

Project description:Analysis of AR-regulation of gene expression. The hypothesis tested in the present study was that AR influences the expression of genes that participate in important bioprocesses in prostate cancer cells, including cell cycle, DNA replication, recombination and repair. Results provide important information on AR-responsive genes that may be crucial to the cell survival and the progression of prostate cancer.

2013-07-28 | GSE49285 | GEO

DHT-AR, E2-AR and R5020-AR target gene profiles in LNCaP

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Genome wide analysis of AR binding sites and histone modifications in prostate cancer

Project description:Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation.We performed ChIP-seq analysis to investigate the role of AR and histone modifications.In addition, by siRNA mediated knockdown of AR-associated factors, changes of AR-binding sites in prostate cancer cells were analyzed.. ChIP-sequence analysis of AR and its associated factors in prostate cancer cells

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2014-10-21 | GSE58309 | GEO

The role of AR-associated factors in androgen signaling

2014-10-21 | E-GEOD-58309 | biostudies-arrayexpress

Genome wide mapping of AR and its associated factors in prostate cancer

Project description:Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation.We performed ChIP-seq analysis to investigate the role of AR and its associated factors such as coregulators or collaborating factors.In addition, by siRNA mediated knockdown of such factors, changes of AR-binding sites in prostate cancer cells were analyzed.

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