Gene expression of T follicular helper (TFH) cells 6 h after ICOS-L blockade
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Joachim GrM-CM-<n
PROVIDER: E-GEOD-49314 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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2014-06-17 | E-GEOD-50677 | biostudies-arrayexpress
Project description:The maintenance of the TFH phenotype depends on continuous signals via ICOS. For a global assessment of differences in gene expression after interruption of the ICOS pathway a genome wide transcriptome analysis was performed. We used the OT-II adoptive transfer system to isolate antigen-specific TFH cells (day 6 after immunization) after short-term (6 hours) blockade of the ICOS pathway using a monoclonal antibody against ICOS-L.
2015-01-19 | GSE49314 | GEO