Affymetrix SNP array data for hepatocellular carcinoma and their adjacent liver tissue samples

ABSTRACT: Chromosomal DNA copy number alterations are a hallmark of human malignancies, including hepatocellular carcinoma (HCC). However, which oncogenes or tumor suppressors located on regions with DNA copy number aberration may contribute to HCC initiation and progression still remain obscure. Here we performed a genome-wide DNA copy number analysis on human HCC samples to identify novel potential oncogenes or tumor suppressors with DNA copy number aberrations. Genome-wide DNA copy numbers analysis was performed with single nucleotide polymorphism micoarray. RT-PCR and immunohistochemical staining were employed to evaluate the NOXIN expression in HCC samples. Colony formation, cell cycle analysis and tumor xenograft assays were performed to assess the role of NOXIN in HCC cells. Reciprocal co-im

ORGANISM(S): Homo sapiens

SUBMITTER: Zeguang Han 

PROVIDER: E-GEOD-49317 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress