Angiotensin converting enzyme inhibition attenuates insterstitial injury in a murine model of chronic glomerulonephritis

ABSTRACT: Evolution of glomerulonephritis (GN) to tubulointerstitial disease is a universal antecedent to the development of chronic kidney disease (CKD). There is also evidence that angiotensin converting enzyme (ACE) inhibition may attenuate the development of CKD in some forms of glomerulonephritis. We tested the role of ACE inhibition in a model of GN in which complement-dependent tubulointerstitial disease develops. GN was induced in C57BL/6 mice with intraperitoneal injections of horse spleen apoferritin (HSA) using lipopolysaccharide (LPS) as an adjuvant. Four groups of six animals were studied: saline-injected control mice treated with captopril or water, and GN mice treated with captopril or water. GN developed in all HSA-treated animals. In those receiving captopril, however, proteinu

ORGANISM(S): Mus musculus

SUBMITTER: Frank Middleton 

PROVIDER: E-GEOD-49323 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress