GATA2 as a potential prostate cancer metastasis-driving gene

ABSTRACT: Metastatic prostate cancer (PCa) is a terminal disease and establishment of novel therapeutic strategy specifically targeting metastasis is critically required for its management. This study was aimed at identifying metastasis-driving genes which could potentially be therapeutic targets for metastatic prostate cancer. Integrative analysis of gene expression profiles from a pair of metastatic and non-metastatic prostate cancer tissue xenografts was used to identify potential prostate cancer metastasis-driving genes. Among the candidate genes found, GATA2, a master regulator gene in the development of hematopoietic system, was particularly interesting since it is an important pioneer factor in the regulation of AR-target gene in prostate cancer. In consistent with our finding, elevated expre

ORGANISM(S): Homo sapiens

SUBMITTER: Shawn Anderson 

PROVIDER: E-GEOD-49342 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress