Expression data from adult ATII and E18 Bipotent progenitor cells in the mouse lung

ABSTRACT: Alveoli are thin-walled sacs that serve as the gas exchange units of the lung. They are affected in devastating lung diseases including COPD, Idiopathic Pulmonary Fibrosis, and the major form (adenocarcinoma) of lung cancer, the leading cause of cancer deaths. The alveolar epithelium is composed of two morphologically distinct cell types: alveolar type (AT) 1 cells, exquisitely thin cells across which oxygen diffuses to reach the blood, and AT2 cells, specialized surfactant-secreting cells. Classical studies suggested that AT1 cells arise from AT2 cells during development and following injury, but more recent studies suggest other sources. Here we use histological and marker analysis, lineage tracing, and clonal analysis in mice to identify alveolar progenitor and stem cells and map t

ORGANISM(S): Mus musculus

SUBMITTER: Mark Krasnow 

PROVIDER: E-GEOD-49346 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress