Factors affecting the gene expression of in vitro cultured human preimplantation embryos

ABSTRACT: Study question: What is the relative effect of common environmental and biological factors on transcriptome changes during human preimplantation development? Summary answer: Developmental stage and maternal age had a larger effect on the global gene expression profile of human preimplantation embryos than the culture medium or oxygen concentration used in in vitro culture. What is known already: Studies on mouse and bovine embryos have shown that different conditions in the in vitro culture of embryos can lead to changes in transcriptome profiles. For humans, an effect of developmental stage on the transcriptome profile of embryos has been demonstrated, but studies on the effect of maternal age or culture conditions are lacking. Participants/materials, setting, methods: Embryos that dev

ORGANISM(S): Homo sapiens

SUBMITTER: Paul Wackers 

PROVIDER: E-GEOD-49374 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress