Gene expression data from mouse HDAC4 KO pups, postnatal day 3

ABSTRACT: Reversible protein acetylation provides a central mechanism for controlling gene expression and cellular signaling events. It is governed by the antagonistic commitment of two enzymes families: the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). HDAC4, like its class IIa counterparts, is a potent transcriptional repressor through interactions with tissue-specific transcription factors via its N-terminal domain. Whilst the lysine deacetylase activity of the class IIa HDACs is much less potent than that of the class I enzymes, HDAC4 has been reported to influence protein deacetylation through its interaction with HDAC3. To investigate the influence of HDAC4 on protein acetylation, we employed the unbiased AcetylScan proteomic screen. We identified many proteins known

ORGANISM(S): Mus musculus

SUBMITTER: Tamara Seredenin 

PROVIDER: E-GEOD-49383 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress