The transcriptome landscape of Prochlorococcus MED4 and the factors for stabilizing the core genome

ABSTRACT: RNA-Seq technique was used to obtain the transcriptome map of Prochlorococcus MED4, including operons, untranslated regions, non-coding RNAs, and novel genes. Genome-wide expression profiles revealed that three factors contribute to core genome stabilization. First, a negative correlation between gene expression levels and protein evolutionary rates was observed. Highly expressed genes were overrepresented in the core genome but not in the flexible genome. Gene necessity was determined as a second powerful constraint on genome evolution through functional enrichment analysis. Third, quick mRNA turnover may increase corresponding proteinsM-bM-^@M-^Y fidelity among genes that were abundantly expressed. Together, these factors influence core genome stabilization during MED4 genome evolution.

ORGANISM(S): Prochlorococcus marinus subsp. pastoris str. CCMP1986

SUBMITTER: Bang Wang 

PROVIDER: E-GEOD-49517 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress