Chromosome conformation capture-on-chip of dexamethasone synchronized cells at several circadian times

ABSTRACT: The spatial organization of genes in the interphase nucleus plays an important role in establishment and regulation of gene expression. The circadian expressed and clock controlled genes represent about 10% of the transcripts in the mammalian cells, however the role of genome topology in the expression of genes in a circadian manner remains to be elucidated. In this study we investigated the characteristics and dynamics of the genomic loci that contact the clock controlled gene Dbp during the circadian cycle. To do so, we combined genome-wide interaction profiling by chromosome conformation capture-on-chip (4C) technology with analyses of circadian gene expression in synchronized mouse embryonic fibroblasts (MEFs). This approach allowed us to elucidate the three-dimensional organization of

ORGANISM(S): Mus musculus

SUBMITTER: Paolo Sassone-Corsi 

PROVIDER: E-GEOD-49582 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress