Transcription profiling of rat liver samples treated with pregnenolone 16alpha-carbonitrile

ABSTRACT: Activation of the pregnane X receptor (NR1I2) by drugs and other xenobiotics stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substrates. We used microarray analysis to identify genes whose expression in rat liver was significantly altered by pregnenolone 16alpha-carbonitrile (PCN) treatment. Experiment Overall Design: We chose to profile the gene expression pattern in the livers of adult rats to test the idea that PCN counteracts a wide variety of stresses by activating genes apart from drug metabolism.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Linda Quattrochi 

PROVIDER: E-GEOD-4959 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress