The role of nicotinamide phosphoribosyltransferase (Nampt) in hippocampal neural stem/progenitor cells

ABSTRACT: Neural stem/progenitor cell (NSPC) proliferation and self-renewal, as well as insult-induced differentiation, decrease markedly with age, but the molecular mechanisms responsible for these declines remain unclear. Here we show that levels of NAD+ and nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in mammalian NAD+ biosynthesis, decrease with age in the hippocampus. Ablation of Nampt in adult NSPCs reduced their pool and proliferation in vivo. The decrease in the NSPC pool during aging can be rescued by enhancing hippocampal NAD+ levels. Nampt is the main source of NSPC NAD+ levels and required for G1/S progression of the NSPC cell cycle. Nampt is also critical for oligodendrocytic lineage fate decisions through a mechanism mediated redundantly by Sirt1 and Si

ORGANISM(S): Mus musculus

SUBMITTER: Liana Stein 

PROVIDER: E-GEOD-49784 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress