Genome-wide DNA Methylation Changes in Skeletal Muscle between Young and Middle-aged Pigs

ABSTRACT: Age-related methylation changes have been identified in various tissues and organisms, yet the underlying DNA methylation alterations in muscle aging process have not been clearly clarified. Whilst, many studies revealed that the structural and functional changes in skeletal muscle during aging process started from the mid-point of lifespan. In this study, we used pigs aged 0.5 year and 7 years, representing young and middle-aged periods. Using methylated DNA immunoprecipitation sequencing, we performed comprehensive genome-wide DNA methylation profiling for longissimus dorsi muscle in young and middle-aged pigs. We found more genes showed differently methylated in genebody. In details, 185 human ortholog genes contained DMRs that located in the promoter region, while 657 genes and 1063 ge

ORGANISM(S): Sus scrofa

SUBMITTER: long jin 

PROVIDER: E-GEOD-49791 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress