Gene expression profiling on innervated and denervated muscles of Smad4 KO and control mice.

ABSTRACT: To identify novel atrophy-related genes, which are controlled by BMP signaling, we performed gene expression profiling on innervated and 14 days denervated muscles of Smad4 knockout and control mice, focusing on genes that were differentially upregulated in denervated Smad4-/- muscles compared to controls. Among the different genes our attention was attracted by a gene that encodes for a novel f-box protein (Fbxo30) belonging to the SCF complex family of the ubiquitin ligases. Cell size is determined by the balance between protein synthesis and degradation. This equilibrium is affected by hormones, nutrients, energy levels, mechanical stress and cytokines. Mutations that inactivate Myostatin lead to important muscle growth in animals and humans. However, the signals and pathways responsibl

ORGANISM(S): Mus musculus

SUBMITTER: Marco Sandri 

PROVIDER: E-GEOD-49826 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress