KDM6 Inhibition induces DNA Damage Response (DDR) during ESC Differentiation but not during self-renewal.

ABSTRACT: The discovery of the first histone demethylase in 2004 (LSD1/KDM1) opened new avenues for the understanding of how histone methylation impacts cellular functions. A great number of histone demethylases have been identified since, which are potentially linked to gene regulation as well as to stem cell self-renewal and differentiation. KDM6A/UTY and KDM6B/JMJD3 are both H3K27me3/2-specific histone demethylases, which are known to play a central role in regulation of posterior development, by regulating HOX gene expression. So far nothing is known about the role of histone lysine demethylases (KDMs) during early hematopoiesis. We are studying the role of KDM6A and KDM6B on self-renewal, global gene expression and on local and global chromatin states in embryonic stem cells (ESCs) and during d

ORGANISM(S): Mus musculus

SUBMITTER: Claus Scholz 

PROVIDER: E-GEOD-49886 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress