Polyamines are critical for the induction of the glutamate decarboxylase-dependent acid resistance system in Escherichia coli

ABSTRACT: As part of our studies on the biological functions of polyamines we have used a mutant of Escherichia coli that lacks all the genes for polyamine biosynthesis for a global transcription analysis on the effect of added polyamines. The most striking early response to polyamine addition is the increased expression of the genes for the glutamate dependent acid resistance system (GDAR) that is essential for the survival of bacteria when passing through the acid environment of the stomach. Not only were the two genes for glutamate decarboxylases (gadA and gadB) and the gene for glutamate -γ-aminobutyrate antiporter (gadC) induced by polyamine addition, but also the various genes involved in the regulation of this system were induced. We confirmed the importance of polyamines for the induction of

ORGANISM(S): Escherichia coli

SUBMITTER: WeiPing Chen 

PROVIDER: E-GEOD-49918 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress