Racial Difference in Human Platelet PAR4 Reactivity Reflects Expression of PCTP and miR-376c

ABSTRACT: Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black (n=70) and white (n=84) subjects. Numerous differentially expressed (DE) RNAs were associated with both race and PAR4 reactivity, including phosphatidylcholine transfer protein (PCTP), and platelets from blacks expressed higher levels of PC-TP protein. Purified platellets were obtained from 154 healthy volunteers not taking blood thinning medication, suffering from blood diseases or otherwise excluded for health reasons. RNA was extracted and profiled on these subjects. Simultaneously, purified platelets were phenotyped using aggregation in response to stimulation with agonist. The agonist response scores and races as ewll as gene

ORGANISM(S): Homo sapiens

SUBMITTER: Chad Shaw 

PROVIDER: E-GEOD-49921 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress