RNA-Seq global gene expression of four Dendritic cells subpopulations from lung (CD8+ and CD8- pDCs, CD103-CD11b+ and CD103+CD11b- cDCs) of influenza infected mice at four time points following infection

ABSTRACT: Hundreds of immune cell types work in coordination to maintain tissue homeostasis. Upon infection, dramatic changes occur with the localization, migration and proliferation of the immune cells to first alert the body of the danger, confine it to limit spreading, and finally extinguish the threat and bring the tissue back to homeostasis. Since current technologies can follow the dynamics of only a limited number of cell types, we have yet to grasp the full complexity of global in vivo cell dynamics in normal developmental processes and disease. Here we devise a computational method, digital cell quantification (DCQ), which combines genomewide gene expression data with an immune cell compendium to infer in vivo dynamical changes in the quantities of 213 immune cell subpopulations. DCQ was ap

ORGANISM(S): Mus musculus

SUBMITTER: Irit Gat-Viks 

PROVIDER: E-GEOD-49932 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress