Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Gene Expression Profiling for Plk2 -/- mammary gland


ABSTRACT: Identify gene expression changes in the absence of Plk2 Disruptions in polarity and mitotic spindle orientation contribute to the progression and evolution of tumorigenesis. However, little is known about the molecular mechanisms regulating these processes in vivo. Here we demonstrate that Polo-like kinase 2 (Plk2) regulates mitotic spindle orientation in the mammary gland and is a putative tumor suppressor. Plk2 is highly expressed in the mammary gland and is required for proper mammary gland development. Loss of Plk2 leads to increased mammary epithelial cell proliferation and ductal hyperbranching. Additionally a novel role for Plk2 in regulating the orientation of the mitotic spindle and maintaining proper cell polarity in the ductal epithelium was discovered. In support of a tumor suppressor function for Plk2, loss of Plk2 increased the formation of lesions in multiparous glands. Collectively, these results demonstrate a novel role for Plk2 in regulating mammary gland development and as a tumor suppressor in mammary tumorigenesis. Disruptions in polarity and mitotic spindle orientation contribute to the progression and evolution of tumorigenesis. However, little is known about the molecular mechanisms regulating these processes in vivo. Here we demonstrate that Polo-like kinase 2 (Plk2) regulates mitotic spindle orientation in the mammary gland and is a putative tumor suppressor. Plk2 is highly expressed in the mammary gland and is required for proper mammary gland development. Loss of Plk2 leads to increased mammary epithelial cell proliferation and ductal hyperbranching. Additionally a novel role for Plk2 in regulating the orientation of the mitotic spindle and maintaining proper cell polarity in the ductal epithelium was discovered. In support of a tumor suppressor function for Plk2, loss of Plk2 increased the formation of lesions in multiparous glands. Collectively, these results demonstrate a novel role for Plk2 in regulating mammary gland development and as a tumor suppressor in mammary tumorigenesis. Comparison between Plk2 +/+ (n=3) and Plk2 -/- (n=3) mouse mammary epithelial cells

ORGANISM(S): Mus musculus

SUBMITTER: Elizabeth Villegas 

PROVIDER: E-GEOD-50003 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Plk2 regulates mitotic spindle orientation and mammary gland development.

Villegas Elizabeth E   Kabotyanski Elena B EB   Shore Amy N AN   Creighton Chad J CJ   Westbrook Thomas F TF   Rosen Jeffrey M JM  

Development (Cambridge, England) 20140305 7


Disruptions in polarity and mitotic spindle orientation contribute to the progression and evolution of tumorigenesis. However, little is known about the molecular mechanisms regulating these processes in vivo. Here, we demonstrate that Polo-like kinase 2 (Plk2) regulates mitotic spindle orientation in the mammary gland and that this might account for its suggested role as a tumor suppressor. Plk2 is highly expressed in the mammary gland and is required for proper mammary gland development. Loss  ...[more]

Similar Datasets

2014-05-20 | GSE50003 | GEO
2022-12-02 | PXD027452 | Pride
2018-08-01 | GSE115204 | GEO
2020-03-28 | GSE147636 | GEO
2024-09-02 | BIOMD0000000699 | BioModels
2024-09-02 | BIOMD0000000702 | BioModels
2024-09-02 | BIOMD0000000701 | BioModels
2019-07-15 | PXD013808 | Pride
2021-05-18 | GSE149977 | GEO
2021-05-18 | GSE149976 | GEO