Affymetrix SNP 6.0 array data for Diffuse Intrinsic Pontine Glioma

ABSTRACT: Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and choosing therapies based on assumptions that DIPGs are molecularly similar to adult disease. Recent studies have unraveled the unique genetic make-up of this brain cancer with nearly 80% harboring a K27M-H3.3 or K27M-H3.1 mutation. However, DIPGs are still thought of as one disease with limited understanding of the genetic drivers of these tumors. To understand what drives DIPGs we integrated whole-genome-sequencing with methylation, expression and copy-number profiling, discovering that DIPGs are three molecularly distinct subgroups (H3-K27M,

ORGANISM(S): Homo sapiens

SUBMITTER: Pawel Buczkowicz 

PROVIDER: E-GEOD-50024 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress