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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiling in murine monocyte-dendritic cell progenitors (MDPs), common monocyte progenitors (cMoPs) and 32Dcl.3 cells transduced with C/EBPalpha and/or IRF8

ABSTRACT: To understand the mechanism by which IRF8 inhibits neutrophil differentiation Murine bone marrow MDPs and cMoPs were isolated by cell sorting from wild-type or Irf8 deficient mice. 32Dcl.3 cells were transduced with retroviruses carrying murine C/EBPalpha cDNA and/or murine Irf8 cDNA. Two independent experiments were performed.

ORGANISM(S): Mus musculus

SUBMITTER: Tomohiko Tamura

PROVIDER: E-GEOD-50052 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Project description:To understand the effect of BCR-ABL and IRF8 on gene expression pattern during in vitro dendritic cell differentiation, microarry analysis was performed. Murine bone marrow Lin- cells were transduced with retroviruses carrying human BCR-ABL cDNA and/or mouse Irf8 cDNA, and then cultured with Flt3L for 5 days. Two independent experiments were performed.

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Gene expression analyses in IRF8-induced monocyte differentiation

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