Unraveling the Sox4-orchestrated pro-B cell differentiation program: Intricate roles of the RAG and CK1ε genes (RNA array)

ABSTRACT: One of the main objective of this study is to identify Sox4 controlled gene networks and their roles in progenitor B cells. Commitment of hematopoietic stem cells to B lineage precursors and development of B lineage precursors into mature B cells is attained through the coordinated function of multiple signaling networks, which are in turn controlled through stringent functioning of stage-specific transcription factors. Here, we describe the essential role of Sox4, an HMG (high mobility group)-box-containing transactivator, in B cell development. In the absence of Sox4, differentiation from pre-pro B to pro-B, from pro-B fraction B to pro-B fraction C and further to the immature B cell stage was severely impaired. Loss of differentiation was associated with reduced expression of Rag1 and R

ORGANISM(S): Mus musculus

SUBMITTER: Xiaoping Sun 

PROVIDER: E-GEOD-50065 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress