Myeloid derived suppressor cells enhance stemness of cancer cells by inducing miRNA101 and suppressing the corepressor CtBP2
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ilona Kryczek
PROVIDER: E-GEOD-50082 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.
Cui Tracy X TX Kryczek Ilona I Zhao Lili L Zhao Ende E Kuick Rork R Roh Michael H MH Vatan Linda L Szeliga Wojciech W Mao Yujun Y Thomas Dafydd G DG Kotarski Jan J Tarkowski Rafał R Wicha Max M Cho Kathleen K Giordano Thomas T Liu Rebecca R Zou Weiping W
Immunity 20130905 3
Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and CSCs in patients with ovarian carcinoma and showed that MDSCs inhibited T cell activation and enhanced CSC gene expression, sphere formation, and cancer metastasis. MDSCs triggered ...[more]
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