Expression data from blood and biopsies of Donor-Specific Antibody positive patients

ABSTRACT: The presence of Donor-Specific anti-HLA Antibodies (DSA) is associated with an increased risk of both acute and chronic antibody-mediated rejection (AMR) in kidney allografts. AMR has remained challenging in kidney transplantation and is the major cause of late allograft loss. However, not all patients with DSA develop AMR, leading to the question of whether this represents accommodation, if other protective mechanisms exist or if this is actually a state of pre-rejection. Clinical and histological features, and gene expression profiles of kidney biopsy and blood samples of donor-specific antibody (DSA)+ patients without rejection were compared to antibody-mediated rejection (AMR) patients to elucidate the mechanisms involved in prevention of AMR. Of the 71 DSA+ patients, 46 had diagnosis

ORGANISM(S): Homo sapiens

SUBMITTER: Pilib Ó Broin 

PROVIDER: E-GEOD-50084 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress