Lung injury induced by common bile duct ligation in mice

ABSTRACT: Liver dysfunction and cirrhosis affect vasculature in several organ systems and cause impairment of organ functions, thereby increasing morbidity and mortality. If a mouse model of hepatopulmonary syndrome (HPS) could be established, greater insight into the genetic basis of the disease would be gained. Our objectives were to establish a mouse model of lung injury after common bile duct ligation (CBDL) and to investigate pulmonary pathogenesis for application in future therapeutic approaches. Balb/c mice were subjected to CBDL. Immunohistochemical analyses and real-time quantitative reverse transcriptional polymerase chain reaction were performed on pulmonary tissues. The presence of HPS markers were detected by western blot and microarray analyses. We observed extensive proliferation of C

ORGANISM(S): Mus musculus

SUBMITTER: Koh-ichi Nakashiro 

PROVIDER: E-GEOD-50088 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress