Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Runx3 function in CD8+ splenic T cells

ABSTRACT: CD8+T cells are immune cells that recognize foreign antigens on infected and tumor cells, leading to cytokine-dependent expansion and activation of cytotoxicity towards the targets. To identify Runx3 responsive genes, CD8+ T cells were isolated from spleen of WT and Runx3-/- mice . Six samples (3 WT and 3 Runx3-/-) of freshly isolated CD8+ T cells (resting) were separately obtained from individual mice.

ORGANISM(S): Mus musculus

SUBMITTER: Joseph Lotem 

PROVIDER: E-GEOD-50119 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Runx3-mediated transcriptional program in cytotoxic lymphocytes.

Lotem Joseph J   Levanon Ditsa D   Negreanu Varda V   Leshkowitz Dena D   Friedlander Gilgi G   Groner Yoram Y  

PloS one 20131113 11

The transcription factor Runx3 is highly expressed in CD8(+) T and NK cytotoxic lymphocytes and is required for their effective activation and proliferation but molecular insights into the transcription program regulated by Runx3 in these cells are still missing. Using Runx3-ChIP-seq and transcriptome analysis of wild type vs. Runx3(-/-) primary cells we have now identified Runx3-regulated genes in the two cell types at both resting and IL-2-activated states. Runx3-bound genomic regions in both  ...[more]

Similar Datasets

Transcriptomics Runx3 function in IL-2-activated splenic CD8+ T cells
2013-11-18 | E-GEOD-50121 | biostudies-arrayexpress
Genomics Genome-wide maps of Runx3 bound regions in splenic CD8+ T cells.
2013-11-18 | E-GEOD-50130 | biostudies-arrayexpress
Transcriptomics Runx3 function in CD4+ splenic dendritic cells
2014-06-22 | E-GEOD-48589 | biostudies-arrayexpress
Transcriptomics Runx3 regulated genes in splenic CD4+ dendritic cells
2014-06-22 | E-GEOD-48591 | biostudies-arrayexpress
Genomics The transcription program of Runx3 in natural killer cells and CD8+ T cells
2013-11-18 | E-GEOD-50131 | biostudies-arrayexpress
Genomics Genome-wide maps of Runx3 bound regions in splenic IL-2-activated CD8+ T cells
2013-11-18 | E-GEOD-50128 | biostudies-arrayexpress
Transcriptomics The affect of specific ablation of Runx3 from Esam splenic dendritic cells
2014-06-22 | E-GEOD-48590 | biostudies-arrayexpress
Transcriptomics Runx3 function in splenic NK cells
2013-11-18 | E-GEOD-50123 | biostudies-arrayexpress
Genomics Genome-wide maps of Runx3 bound regions in CD4 splenic dendritic cells.
2014-06-22 | E-GEOD-48588 | biostudies-arrayexpress
Transcriptomics Runx3 function in splenic NK cells activated in vivo by IL-15.
2014-01-22 | E-GEOD-50120 | biostudies-arrayexpress