Transcription profiling of rat nasal respiratory and olfactory epithelium

ABSTRACT: The nasal epithelium is an important target site for chemically-induced toxicity and carcinogenicity. Human epidemiological investigations and experimental laboratory animal studies show that the nasal olfactory epithelium is selectively damaged by inhalation exposure to several chemicals, including vinyl acetate and hydrogen sulfide. The reason for the relative sensitivity of the nasal olfactory epithelium is not known. To better understand and predict the response of the nasal epithelium to inhaled xenobiotics, gene expression profiles from naїve male and female Sprague-Dawley rats were constructed. Epithelial cells were manually collected from the nasal septum, naso- and maxillo-turbinates, and ethmoid turbinates of 9 male and 9 female rats. Gene expression analysis was performed

ORGANISM(S): Rattus norvegicus

SUBMITTER: Elizabeth Sherman Roberts 

PROVIDER: E-GEOD-5019 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress