Expression data for human retinal pigment epithelium (RPE)/choroid - early age-related macular degeneration (AMD) and control samples

ABSTRACT: Purpose: Age-related degeneration (AMD) is a major cause of blindness in developed countries. The molecular pathogenesis of early events in AMD is poorly understood. We investigated differential gene expression in samples of human retinal pigment epithelium (RPE)/choroid from early AMD and control maculas using exon-based arrays. Methods: Gene expression levels in nine early AMD and nine control human donor eyes were assessed using Affymetrix Human Exon ST 1.0 arrays. Two controls did not pass quality control and were removed. Differentially expressed genes were annotated using DAVID, and gene set enrichment analysis (GSEA) was performed on RPE-specific and endothelium-associated gene sets. CFH genotype was also assessed and differential expression was analyzed with respect to high AMD ris

ORGANISM(S): Homo sapiens

SUBMITTER: S. Scott Whitmore 

PROVIDER: E-GEOD-50195 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress