Regulation of the raffinose and melezitose utilization operons of B. breve UCC2003

ABSTRACT: Members of the genus Bifidobacterium are Gram-positive bacteria which are commonly found in the gastrointestinal tract (GIT) of mammals, including humans. Growth of bifidobacteria has been shown to be selectively stimulated by various carbohydrates found in the human diet. To extend our understanding of the regulation of bifidobacterial carbohydrate utilization systems, we investigated the regulation of two carbohydrate utilisation clusters dedicated to the metabolism of raffinose type sugars and melezitose. Transcriptomic and functional genomic approaches clearly identified that the raffinose utilisation system is positively regulated by the activator RafR, while the melezitose utilisation system is negatively regulated by lacI type transcriptional regulators. A B. breve UCC2003-rafR in

ORGANISM(S): Bifidobacterium breve UCC2003

SUBMITTER: Mary O'Connell Motherway 

PROVIDER: E-GEOD-50211 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress