DNA Methylation Changes in Allergic Patients Correlate with Symptom Severity [methylation]

ABSTRACT: Altered DNA methylation patterns in CD4+ T-cells indicate the importance of epigenetic mechanisms in inflammatory diseases. However, the identification of these alterations is complicated by the heterogeneity of most inflammatory diseases. Seasonal allergic rhinitis (SAR) is an optimal disease model for the study of DNA methylation because of its well-defined phenotype and etiology. We generated genome-wide DNA methylation (Npatients = 8, Ncontrols = 8) and gene expression (Npatients= 9, Ncontrols = 10) profiles of CD4+ T-cells from SAR patients and healthy controls using Illumina’s HumanMethylation450 and HT-12 microarrays, respectively. DNA methylation profiles clearly and robustly distinguished SAR patients from controls, during and outside the pollen season. Moreover, we found that thi

ORGANISM(S): Homo sapiens

SUBMITTER: Colm Nestor 

PROVIDER: E-GEOD-50222 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress