Expression profiling of the retinal pigment epithelium in zebrafish smarca4 mutant

ABSTRACT: Purpose: The purpose of this study was to develop a framework for analyzing RPE expression profiles from zebrafish eye mutants. Methods: The fish model we used was smarca4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4), a retinal dystrophic mutant that the retinal phenotype and expression profiles were previously characterized. Histological and Affymetrix GeneChip analyses were conducted to define the RPE defects and underlying differential expression respectively. Results: Histological analysis indicates that smarca4 RPE was formed but its differentiation was abnormal. In particular, ultra-structural analysis of smarca4 RPE by transmission electron microscopy showed a number of defects in melanogenesis, suggesting that the cytoskele

ORGANISM(S): Danio rerio

SUBMITTER: Yuk Fai Leung 

PROVIDER: E-GEOD-50241 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress