Global transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Joao Fadista
PROVIDER: E-GEOD-50398 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
TCF7L2 is a master regulator of insulin production and processing.
Zhou Yuedan Y Park Soo-Young SY Su Jing J Bailey Kathleen K Ottosson-Laakso Emilia E Shcherbina Liliya L Oskolkov Nikolay N Zhang Enming E Thevenin Thomas T Fadista João J Fadista João J Bennet Hedvig H Vikman Petter P Wierup Nils N Fex Malin M Rung Johan J Wollheim Claes C Nobrega Marcelo M Renström Erik E Groop Leif L Hansson Ola O
Human molecular genetics 20140711 24
Genome-wide association studies have revealed >60 loci associated with type 2 diabetes (T2D), but the underlying causal variants and functional mechanisms remain largely elusive. Although variants in TCF7L2 confer the strongest risk of T2D among common variants by presumed effects on islet function, the molecular mechanisms are not yet well understood. Using RNA-sequencing, we have identified a TCF7L2-regulated transcriptional network responsible for its effect on insulin secretion in rodent and ...[more]
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