Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Marc Uldry
PROVIDER: E-GEOD-5041 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell metabolism 20060501 5
Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1alpha. We could then efficiently knockdown PGC-1beta expression by shRNA expression. Loss of PGC-1alpha did not alter brown fat differentiation but severely reduced the induction of thermoge ...[more]