Identification of CpG island methylator phenotype predicts the prognosis of small cell lung cancer

ABSTRACT: We analyzed 28 fresh frozen samples from pure SCLC patients and 13 noncancerous lung tissues, using the Illumina Infinium 27k Human DNA methylation Beadchip v1.2 Background: Small cell lung cancer (SCLC) accounts for 13-15% of new lung cancer cases in worldwide and has the poor therapeutic outcomes with a median survival of just over one year. A CpG island methylate phenotype (CIMP) is well known as a methylator phenotype with characteristic promoter DNA methylation alterations, in colorectal cancers, glioblastoma and breast cancers, although there has been no report about any CIMP of SCLC. We investigated whether DNA methylation profiles can provide useful molecular subtyping of SCLC in terms of etiology and prognosis of SCLC. Results: We selected a total of 1741 most differentially meth

ORGANISM(S): Homo sapiens

SUBMITTER: YUICHI SAITO 

PROVIDER: E-GEOD-50412 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress