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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Characterizing the wound healing response that drives human epidermal maturation on transcriptome level

ABSTRACT: We collected biopsies from patients undergoing split-thickness skin graft harvesting. The first biopsy was collected from the intact skin before wounding and the second and third from the donor site wound on 14th and 21st day post-operatively. A genome-wide microarray was then executed from each sample, and the gene profiles of each time point were compared. 12 samples from 4 patients were analyzed

ORGANISM(S): Homo sapiens

SUBMITTER: Kristo Nuutila

PROVIDER: E-GEOD-50425 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Human Skin Transcriptome during Epidermal Wound Healing

Project description:In order to clarify the human response of re-epithelialization, we biopsied split-thickness skin graft donor site wounds immediately before and after harvesting, as well as during the healing process 3 and 7 days thereafter. Altogether 25 biopsies from 8 patients qualified for the study. All samples were analysed by genome-wide microarrays. Here we identified the genes associated with normal skin re-epithelialization on time-scale, and organized them by similarities according to their induction or suppression patterns during wound healing. Overall 25 samples were analyzed

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Characterizing the wound healing response that drives human epidermal maturation on transcriptome level

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Gene expression profiling of negative-pressure-treated split-thickness skin graft donor site wounds reveals novel effects on epithelialization

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