The molecular phenotype of endocapillary proliferation in IgA nephropathy and potential modulation by bioactive small molecules

ABSTRACT: Endocapillary proliferation is associated with higher risk of progressive disease in IgAN. To better understand molecular pathways involved in the development of endocapillary proliferation and to identify novel specific therapeutic targets, we evaluated the glomerular transcriptome of microdissected kidney biopsies from 22 patients with IgAN. Endocapillary proliferation was defined according to the Oxford scoring system by 3 nephropathologists. We analyzed mRNA expression using microarrays and identified transcripts differentially expressed in patients with endocapillary proliferation. Next, we employed both transcription factor analysis and in silico drug screening and confirmed that the endocapillary proliferation transcriptome is significantly enriched with pathways modulated by co

ORGANISM(S): Homo sapiens

SUBMITTER: Celine Berthier 

PROVIDER: E-GEOD-50469 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress