Aurora kinase inhibition triggers senescence in human melanoma cells

ABSTRACT: Phenotypically, there is a heterogeneous response of cancer cells to chemotherapy or targeted therapy. While therapeutically much attention is focused on cell death, there is growing evidence suggesting that a subpopulation of cancer cells undergo therapy-induced senescence. Depending on the therapy, dose and timing, senescence may be a dominant phenotype over cell death. An integrated FACS approach identified two types of therapy-induced senescence in human melanoma cells, irreversible senescence induced by Aurora kinase inhibition vs. transient senescence induced by B-RAF kinase inhibition. Autophagy and ER stress response precede and are required for therapy-induced senescence in cancer cells, mirroring their functions in normal cells undergoing oncogene-induced senescence. Importantly,

ORGANISM(S): Homo sapiens

SUBMITTER: Xiaowei Xu 

PROVIDER: E-GEOD-50474 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress