Histone Demethylase JARID1B Controls Mammary Gland Development by Regulating Key Developmental Genes

ABSTRACT: The jmjC-domain containing H3K4 histone demethylase JARID1B/KDM5B/PLU1 is over-expressed in human breast cancer and is a potential target for breast cancer treatment. To investigate the in vivo function of JARID1B, we developed a new strain of Jarid1b knockout mice and characterized the phenotypes in detail. Unlike previously reported knockout strains, the majority of our Jarid1b knockout mice are viable beyond embryonic and neonatal stages. Nonetheless, these mice exhibit decreased body weight, higher incidence of adult mortality and decreased female fertility. Furthermore, Jarid1b knockout mice show delayed mammary gland development. Mechanistically, loss of JARID1B leads to decreased serum estrogen levels and reduced proliferation of mammary epithelial cells in early puberty. In addit

ORGANISM(S): Mus musculus

SUBMITTER: Valentina Greco 

PROVIDER: E-GEOD-50479 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress