Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cells

ABSTRACT: Cervical cancer is the second most common malignancy in women worldwide, with high risk subtypes of human papillomavirus (HPV) constituting the major etiological agent. However, only a small percentage of women infected by the virus develop disease suggesting that additional host genetic alterations are necessary for disease progression. In this study we examined the genomes of a panel of commonly used model cervical cancer cell lines using a recently developed whole genome tiling path array for CGH analysis. Detailed analysis of genomic profiles enabled the detection of many novel aberrations which may have been missed by conventional cytogenetic methods. In total, 27 minimal regions of recurrent copy number alteration were identified that are potentially involved in tumorigenesis. In

ORGANISM(S): Homo sapiens

SUBMITTER: Wan Lam 

PROVIDER: E-GEOD-5049 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress