Identify genes regulated by zip-2 in absence and presence of P. aeruginosa PA14 infection at 4h

ABSTRACT: Very little is known about how animals discriminate pathogens from innocuous microbes. To address this question, we examined infection-response gene induction in the nematode Caenorhabditis elegans. We focused on genes that are induced in C. elegans by infection with the bacterial pathogen Pseudomonas aeruginosa, but are not induced by an isogenic attenuated gacA mutant. Most of these genes are induced independently of known immunity pathways. We generated a GFP reporter for one of these genes, infection response gene 1 (irg-1), which is induced strongly by wild-type P. aeruginosa strain PA14, but not by other C. elegans pathogens or by other wild-type P. aeruginosa strains that are weakly pathogenic to C. elegans. To identify components of the pathway that induces irg-1 in response to inf

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Emily Troemel 

PROVIDER: E-GEOD-50513 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress