Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MRNA and microRNA in spleens of miR-17~92 transgenic mice

ABSTRACT: spleen B-cells isolated from 9 mice of 6-9 months of age were profilied for mRNA expression using 3D-gene. 3 transgenic mice from two founder lines and 3 wild types as control

ORGANISM(S): Mus musculus

SUBMITTER: Sukhinder Sandhu 

PROVIDER: E-GEOD-50559 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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B-cell malignancies in microRNA Eμ-miR-17~92 transgenic mice.

Sandhu Sukhinder K SK   Fassan Matteo M   Volinia Stefano S   Lovat Francesca F   Balatti Veronica V   Pekarsky Yuri Y   Croce Carlo M CM  

Proceedings of the National Academy of Sciences of the United States of America 20131021 45

miR-17∼92 is a polycistronic microRNA (miR) cluster (consisting of miR-17, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a) which frequently is overexpressed in several solid and lymphoid malignancies. Loss- and gain-of-function studies have revealed the role of miR-17∼92 in heart, lung, and B-cell development and in Myc-induced B-cell lymphomas, respectively. Recent studies indicate that overexpression of this locus leads to lymphoproliferation, but no experimental proof that dysregulation of t  ...[more]

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