Slit2/Robo axis is mandatory for neural remodeling in pancreatic cancer.

ABSTRACT: Pancreatic Ductal Adenocarcinoma (PDA) is a critical health issue in cancer field with little new therapeutic options. Several evidences support an implication of intra-tumoral microenvironment (stroma) on PDA progression. However, its contribution to the role of neuroplastic changes within pathophysiology and clinical course of PDA, mainly through tumor recurrence and neuropathic pain, remains unknown neglecting a putative therapeutic window. Here, we report that intra-tumoral microenvironment is a mediator of PDA Associated Neural Remodeling (PANR). With laser capture microdissection of stromal/tumoral compartment from human PDA followed by cDNA based microarray analyses we highlighted numerous factors expressed by stromal compartment that could impact on neuroplastic changes; among them

ORGANISM(S): Homo sapiens

SUBMITTER: Ezequiel Calvo 

PROVIDER: E-GEOD-50570 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress