Global microarray analysis of changes of gene expression in the epidermis of K14-caSmad1 mice

ABSTRACT: Bone morphogenetic protein (BMP) signalling plays a key role in the control of skin development and postnatal remodelling by regulating keratinocyte proliferation, differentiation and apoptosis. To study the role of BMPs in wound-induced epidermal repair, we used transgenic mice overexpressing the BMP downstream component Smad1 under the control of a K14 promoter as an in vivo model, as well as ex vivo and in vitro assays. K14-caSmad1 mice exhibited retarded wound healing associated with significant inhibition of proliferation and increased apoptosis in healing wound epithelium. Furthermore, microarray and qRT-PCR analyses revealed decreased expression of a number of cytoskeletal/cell motility-associated genes including wound-associated keratins (Krt16, Krt17) and Myo5a, in the epidermis o

ORGANISM(S): Mus musculus

SUBMITTER: Natalia Botchkareva 

PROVIDER: E-GEOD-50578 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress