The Functional Consequences of Variation in Transcription Factor Binding

ABSTRACT: One goal of human genetics is to understand how the information for precise and dynamic gene expression programs is encoded in the genome. The interactions of transcription factors (TFs) with DNA regulatory elements clearly play an important role in determining gene expression outputs, yet the regulatory logic underlying functional transcription factor binding is poorly understood. Many studies have focused on characterizing the genomic locations of TF binding, yet it is unclear to what extent TF binding at any specific locus has functional consequences with respect to gene expression output. To evaluate the context of functional TF binding we knocked down 59 TFs and chromatin modifiers in one HapMap lymphoblastoid cell line. We then identified genes whose expression was affected by the kn

ORGANISM(S): Homo sapiens

SUBMITTER: Darren Cusanovich 

PROVIDER: E-GEOD-50588 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress