Variability in white blood cell counts in swine: identification of putative positional and functional candidate genes by a transcriptome-based study

ABSTRACT: The counts of total white blood cells (WBCs) and WBC subsets are well-established diagnostic factors for various diseases. It has been shown that variations in WBC counts are significantly controlled by individuals’ genetics in swine. However, despite detection of quantitative trait loci (QTLs) for these phenotypes, little is known on the molecular basis underlying their variations. Our aim was to study gene profiling variations according to variations in WBC counts and to connect results with available QTL mapping. Whole blood transcriptome of animals contrasted for levels of WBC counts were compared. A pig generic microarray enriched in immunity-related genes was used. 378 probes representing 334 genes were found significantly differentially expressed between high- and low-count WBC grou

ORGANISM(S): Sus scrofa

SUBMITTER: Yu GAO 

PROVIDER: E-GEOD-50589 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress