Fibroblast cells immediate-early after human cytomegalovirus infection

ABSTRACT: Human cytomegalovirus (HCMV) has been shown to have the potential to alter cellular gene expression early after infection. However, one-gene approaches and the use of closed system gene expression technologies have identified only few cellular genes whose activity changed immediate-early. We therefore used serial analysis of gene expression (SAGE) to investigate the transcriptional program of human fibroblasts in response to HCMV in the immediate-early phase of infection. Differential expression of various cellular genes was monitored. Transcriptional expression changes of genes coding for ribosomal proteins reflected a general cellular response to starvation and stress. But differential regulation of genes coding for transcription factors and proteins associated with cellular metabolism,

ORGANISM(S): Homo sapiens

SUBMITTER: Marc Kenzelmann 

PROVIDER: E-GEOD-506 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress